Sulfonamide Resistance of Clostridium Sporogenes.

Bacteria which are sulfonamide-sensitive have been reported to be incapable of the rapid utilization of folic acid for inhibition reversal (Alimchandani and Sreenivasan, J. Bacteriol. 73:538, 1957; Krieg and Pelczar, J. Bacteriol. 80:242, 1960; Davis and Feingold, p. 343. In I. C. Gunsalus and R. Y. Stanier [ed.], The Bacteria, vol. 4, Academic Press, Inc., New York, 1962), presumably because of impermeability or lack of a folic reductase. In this report, we describe an organism sensitive to sulfathiazole in the absence of folic acid but not in its presence. Growth inhibition reversal experiments employed Clostridium sporogenes ATCC 11437, and